ARGIRELINE

Argireline
SUMMARY
Two cutting edge technologies have permitted the discovery and production of ARGIRELINE®: COMBINATION CHEMISTRY and PEPTIDE SOLID PHASE SYNTHESIS. The anti-wrinkle hexapeptide ARGIRELINE® represents the discovery of a positive hit based on a scientifically pathway from rational design to GMP production analysis to measure the effectiveness of an O/W emulsion containing 10% of ARGIRELINE® 0.5 g/mL of pure hexapeptide on healthy women volunteers, confirmed the validation of the biochemical mechanism.
THE PRODUCT
One of the most striking signs of aging is increased wrinkling of the face. This can occur naturally over time and is identified by certain biochemical, histological and physiological changes that are enhanced by environmental exposure. There are other secondary factors that can cause characteristic folds, furrows and creases of the face. These include the constant pull of gravity, frequent and constant positional pressure of the skin of the face (e.g. during sleep) or repeated facial movements caused by the contraction of muscles of facial expression. In any case and independently on the ultimate physiological pathway, the molecular mechanism involved in face aging is directly related to the changes in the conformation of the collagen triple helix, degradation of the elastic polypeptides and certain disorder in the packing of the lipidic matrix of the skin. On the other hand, it has been clearly established in recent publications that these conformational changes and the disturbance of the perfect packing of the lipid matrix can be significantly avoided by inhibiting:
a) the formation of the SNARE complex
b) the release of the Catecholamines
THE COSMETIC BENEFITS OF ARGIRELINE®
A). ARGIRELINE® reduces the depth of the wrinkles in the face caused by the contraction of the muscles of facial expression, especially in the front and around the eyes.
B). ARGIRELINE® prevents aging of the skin induced by repeated facial movements mediated by excessive catecholamines release.
THE COSMETIC APPLICATIONS
ARGIRELINE® can be incorporated in cosmetic formulations such as emulsions, gels, serums, etc., where removal of the deep lines or wrinkles in the front or around the eyes area is claimed.